Thionyl Chloride → HCID 16749887, 화합물

HRID 1677655

반응식

HRID 1677655 반응식
O[C:2]1([C:10]2[CH:17]=[CH:16][C:13]([C:14]#[N:15])=[CH:12][CH:11]=2)[C:9]2[N:5]([CH:6]=[N:7][CH:8]=2)[CH2:4][CH2:3]1.S(Cl)(Cl)=O.C(=O)([O-])O.[Na+]>C(Cl)(Cl)Cl>[CH:8]1[N:7]=[CH:6][N:5]2[CH2:4][CH2:3][CH:2]([C:10]3[CH:17]=[CH:16][C:13]([C:14]#[N:15])=[CH:12][CH:11]=3)[C:9]=12

참가 물질

5

반응물 3

HCID 24386Thionyl ChlorideHCID 516892Sodium BicarbonateHCID 669339384-(7-hydroxyl-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)benzonitrile

생성물 1

HCID 16749887HCID 16749887, 화합물

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

A solution of 4 mmol of 4-(7-hydroxyl-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)benzonitrile and 8 mmol of thionyl chloride in 30 ml of chloroform is heated at reflux for 15 hours. The reaction mixture is cooled to room temperature and poured into saturated sodium hydrogen carbonate solution. The phases are separated and the organic phase is washed with brine, dried with sodium sulphate and evaporated. From the residue the title compound is obtained by means of flash chromatography (SiO2 60F).

후처리

  1. temperatureat reflux for 15 hours
  2. customThe phases are separated
  3. washthe organic phase is washed with brine
  4. dry with materialdried with sodium sulphate
  5. customevaporated

출처 및 근거

ORD 기록
ord-c507ccd62389485bb310e8da8c447361
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08008334B2

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