Hydrochloric Acid → 1-(5-(2-Thienyl)-1,2,4-oxadiazol-3-yl)piperazine, dihydrochloride

HRID 1677763노트

반응식

HRID 1677763 반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[O:10][N:9]=[C:8]([N:11]2[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]2)[N:7]=1.[ClH:24]>CCOCC>[ClH:24].[ClH:24].[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[O:10][N:9]=[C:8]([N:11]2[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]2)[N:7]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 58487964Tert-butyl 4-(5-(2-thienyl)-1,2,4-oxadiazol-3-yl)piperazine-1-carboxylate

생성물 1

HCID 1317291271-(5-(2-Thienyl)-1,2,4-oxadiazol-3-yl)piperazine, dihydrochloride수율 78%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A solution of tert-butyl 4-(5-(2-thienyl)-1,2,4-oxadiazol-3-yl)piperazine-1-carboxylate (2.2 g) in 2M HCl in Et2O (50 mL) was stirred at RT for 6 hours. The solvent was removed under vacuum to give 1.6 g (78%) of The title compound as a solid. TLC—CHCl3/MeOH (8/2): Rf=0.2. HPLC purity >98%.

후처리

  1. customThe solvent was removed under vacuum

출처 및 근거

ORD 기록
ord-2e02afd8db8b4f998dea10ee739aa0f9
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08008302B2

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