Water → 3-(4-Methyl-1H-imidazol-1-YL)-5-(trifluoromethyl)benzonitrile

HRID 1678348노트

반응식

HRID 1678348 반응식
[CH3:1][C:2]1[N:3]=[CH:4][NH:5][CH:6]=1.[H-].[Na+].F[C:10]1[CH:11]=[C:12]([CH:15]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:17]=1)[C:13]#[N:14].O>CN1CCCC1=O>[CH3:1][C:2]1[N:3]=[CH:4][N:5]([C:10]2[CH:17]=[C:16]([C:18]([F:19])([F:21])[F:20])[CH:15]=[C:12]([CH:11]=2)[C:13]#[N:14])[CH:6]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 24758Sodium hydrideHCID 5190373-Fluoro-5-(trifluoromethyl)benzonitrileHCID 178418800HCID 178418800, 화합물

생성물 1

HCID 469003933-(4-Methyl-1H-imidazol-1-YL)-5-(trifluoromethyl)benzonitrile

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매3회

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온도
22.5 °C

실험 절차

A solution of 4-methyl-1H-imidazole (1.98 g, 24.11 mmol) in N-methylpyrrolidinone (NMP) (18 mL) is added to a solution of sodium hydride (0.82 g, 60%, 20.5 mmol) in NMP (18 mL) at 20-25° C. under an atmosphere of nitrogen. The mixture is stirred for 1 hour, before a solution of 3-fluoro-5-trifluoromethyl benzonitrile (XXI) (3.2 g, 16.4 mmol) in NMP (8 mL) is added. The reaction mixture is stirred for 2 hours at 20-25° C. and then water (120 mL) is added within 20 minutes and the resulting suspension is stirred for 16 hours.

후처리

  1. additionis added
  2. stirringthe resulting suspension is stirred for 16 hours

출처 및 근거

ORD 기록
ord-f70f3809d61242f0a8903fadbc8f246e
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08008504B2

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