Acetic Acid → 9H-fluorene-2-carbonitrile

HRID 1678372노트

반응식

HRID 1678372 반응식
[CH:1]1[C:13]2[CH2:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][C:2]=1[CH:14]=O.C([O-])(=O)C.[Na+].[Cl-].O[NH3+:23].C(O)(=O)C>O>[C:14]([C:2]1[CH:3]=[CH:4][C:5]2[C:6]3[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=3)[CH2:12][C:13]=2[CH:1]=1)#[N:23]

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 21645Hydroxylamine HClHCID 34804Fluorene-2-carboxaldehydeHCID 517045Sodium Acetate

생성물 1

HCID 173029H-fluorene-2-carbonitrile수율 63.3%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

25 g of 2-fluorenecarboaldehyde, 11.6 g of sodium acetate, 9.7 g of hydroxy ammonium chloride and 150 ml of acetic acid were stirred at 130 for 18 hours. The reaction mixture was allowed to room temperature, poured into 200 ml of water and the precipitate was collected by filtration. The crude product was purified by column chromatography, giving 15.57 g (63%) of 2-cyanofluorene.

후처리

  1. customwas allowed to room temperature
  2. filtrationthe precipitate was collected by filtration
  3. customThe crude product was purified by column chromatography

출처 및 근거

ORD 기록
ord-c38194389ac749a1a244c711695c52a3
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08008507B2

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