Cyanuric chloride → 1-(4,6-dichloro-1,3,5-triazin-2-yl)-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

HRID 1678417

반응식

HRID 1678417 반응식
[F:1][C:2]([F:20])([F:19])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][NH:10][C:11]([CH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1)=[O:12].[N:21]1[C:28]([Cl:29])=[N:27][C:25](Cl)=[N:24][C:22]=1[Cl:23].C(N(C(C)C)CC)(C)C>C(#N)C>[Cl:23][C:22]1[N:21]=[C:28]([Cl:29])[N:27]=[C:25]([N:16]2[CH2:17][CH2:18][CH:13]([C:11]([NH:10][CH2:9][C:4]3[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=3[C:2]([F:1])([F:19])[F:20])=[O:12])[CH2:14][CH2:15]2)[N:24]=1

참가 물질

5

반응물 3

HCID 7954Cyanuric chlorideHCID 81531DiisopropylethylamineHCID 59614575N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

생성물 1

HCID 866443151-(4,6-dichloro-1,3,5-triazin-2-yl)-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a solution of N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide (950 mg, 3.32 mmol, 1.00 equiv) in acetonitrile (30 ml) at room temperature, cyanuric chloride (612 mg, 3.32 mmol, 1.00 equiv) and diisopropylethylamine (DIEA, 1.74 ml, 9.95 mmol, 3.00 equiv) were added dropwise. The reaction was stirred at room temperature for 3 h. Without workup or purification, the reaction mixture was carried forward to the next step. MS (ES+): m/e 435.9 [M+H]+

후처리

  1. customWithout workup or purification

출처 및 근거

ORD 기록
ord-2dba5bfded25437cb075a8b26a9da52b
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08008483B2

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