5'-[2-(tert-Butoxycarbonyl-methyl-amino)-acetylamino]-2'-chloro-biphenyl-4-carboxylic acid ethyl ester → 5'-[2-(tert-Butoxycarbonyl-methyl-amino)-acetylamino]-2'-chloro-biphenyl-4-carboxylic acid

HRID 1678518노트

반응식

HRID 1678518 반응식
C([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[C:16]([NH:18][C:19](=[O:30])[CH2:20][N:21]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[CH3:22])[CH:15]=[CH:14][C:13]=2[Cl:31])=[CH:8][CH:7]=1)=[O:5])C>[OH-].[Na+].C(O)C>[C:26]([O:25][C:23]([N:21]([CH3:22])[CH2:20][C:19]([NH:18][C:16]1[CH:15]=[CH:14][C:13]([Cl:31])=[C:12]([C:9]2[CH:8]=[CH:7][C:6]([C:4]([OH:5])=[O:3])=[CH:11][CH:10]=2)[CH:17]=1)=[O:30])=[O:24])([CH3:29])([CH3:28])[CH3:27]

참가 물질

4

반응물 1

HCID 673712285'-[2-(tert-Butoxycarbonyl-methyl-amino)-acetylamino]-2'-chloro-biphenyl-4-carboxylic acid ethyl ester

생성물 1

HCID 673744955'-[2-(tert-Butoxycarbonyl-methyl-amino)-acetylamino]-2'-chloro-biphenyl-4-carboxylic acid

시약·촉매·용매 2

HCID 702Ethanol용매HCID 14798Sodium Hydroxide용매

실험 절차

5′-[2-(tert-Butoxycarbonyl-methyl-amino)-acetylamino]-2′-chloro-biphenyl-4-carboxylic acid ethyl ester (494 mg) in 2M NaOH (10 ml) and ethanol (15 ml) was stirred at room temp for 18 h. The ethanol was then evaporated and the residue acidified with HCl. The colourless solid formed was collected by filtration and dried (420 mg).

후처리

  1. customThe ethanol was then evaporated
  2. customThe colourless solid formed
  3. filtrationwas collected by filtration
  4. customdried (420 mg)

출처 및 근거

ORD 기록
ord-d8a6323c848a497ea91c5dbaaef6b134
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08008303B2

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