4-Methylmorpholine → 2'-Chloro-5'-(2-fluoro-4-morpholin-4-yl-phenylcarbamoyl)-biphenyl-4-carboxylic acid ethyl ester

HRID 1678534노트

반응식

HRID 1678534 반응식
[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[C:17]([Cl:18])=[CH:16][CH:15]=[C:14]([C:19]([OH:21])=O)[CH:13]=2)=[CH:8][CH:7]=1)=[O:5])[CH3:2].[F:22][C:23]1[CH:24]=C(N)[CH:26]=[CH:27][C:28]=1[N:29]1CCOCC1.CCN=C=NCCCN(C)C.C1C=CC2N(O)N=NC=2C=1.[CH3:57][N:58]1[CH2:63][CH2:62][O:61][CH2:60][CH2:59]1>CN(C=O)C.O>[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[CH:8][C:9]([C:12]2[CH:13]=[C:14]([C:19](=[O:21])[NH:29][C:28]3[CH:27]=[CH:26][C:57]([N:58]4[CH2:63][CH2:62][O:61][CH2:60][CH2:59]4)=[CH:24][C:23]=3[F:22])[CH:15]=[CH:16][C:17]=2[Cl:18])=[CH:10][CH:11]=1)=[O:5])[CH3:2]

참가 물질

8

반응물 5

HCID 79724-MethylmorpholineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 14853303-Fluoro-4-morpholinoanilineHCID 532278844-Chloro-3-(4-ethoxycarbonylphenyl)benzoic acid

생성물 1

HCID 673712232'-Chloro-5'-(2-fluoro-4-morpholin-4-yl-phenylcarbamoyl)-biphenyl-4-carboxylic acid ethyl ester

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

A mixture of 6-chloro-biphenyl-3,4′-dicarboxylic acid 4′-ethyl ester (213 mg), 3-fluoro-4-morpholin-4-yl-phenylamine (179 mg), EDAC (174 mg), HOBT (123 mg) and N-methylmorpholine (200 μl) in DMF (3 ml) was stirred at room temperature. After 11 h, water (30 ml) was added and the resulting suspension filtered. The residue was then purified by chromatography. Elution with 1:1 ethyl acetate:petrol gave a brown oil (235 mg).

후처리

  1. filtrationthe resulting suspension filtered
  2. customThe residue was then purified by chromatography
  3. washElution with 1:1 ethyl acetate

출처 및 근거

ORD 기록
ord-2a74595c25314e6dad8db0b72a887e34
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08008303B2

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