Hydrochloric Acid → HCID 178479189, 화합물

반응식

C([NH:4][CH2:5][C:6]1[S:10][C:9]([SH:11])=[N:8][N:7]=1)(=O)C.[ClH:12]>>[ClH:12].[NH2:4][CH2:5][C:6]1[S:10][C:9]([SH:11])=[N:8][N:7]=1

참가 물질

반응물 2

HCID 313Hydrochloric Acid

HCID 178474654HCID 178474654, 화합물

생성물 1

HCID 178479189HCID 178479189, 화합물

실험 절차

Thus obtained 5-acetamidomethyl-1,3,4-thiadiazole-2-thiol (44 g) was suspended in 6N hydrochloric acid (400 ml) and the mixture was heated to reflux for 2 hours. The reaction mixture was allowed to cool, and the precipitates were collected by filtration and washed with ethanol to give 5-aminomethyl-1,3,4-thiadiazole-2-thiol hydrochloride (28.3 g). m.p. 213° to 217° C. The mother liquid obtained above was concentrated under reduced pressure and the residue was washed with ether to give the same objective product (12.6 g). Total yield is 40.9 g.

후처리

temperaturethe mixture was heated
temperatureto reflux for 2 hours
temperatureto cool
filtrationthe precipitates were collected by filtration
washwashed with ethanol

출처 및 근거

ORD 기록: ord-048bb7ea113e485dbd360c293ae1a877
출처 데이터셋: uspto-grants-1978_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04077965

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