Sodium Hydroxide → 2-[4-(Oxan-4-yl)phenoxy]propanoic acid

HRID 1678974노트

반응식

HRID 1678974 반응식
[O:1]1[CH2:6][CH2:5][CH:4]([C:7]2[CH:20]=[CH:19][C:10]([O:11][CH:12]([CH3:18])[C:13]([O:15]CC)=[O:14])=[CH:9][CH:8]=2)[CH2:3][CH2:2]1.[OH-].[Na+]>C(O)C>[O:1]1[CH2:2][CH2:3][CH:4]([C:7]2[CH:8]=[CH:9][C:10]([O:11][CH:12]([CH3:18])[C:13]([OH:15])=[O:14])=[CH:19][CH:20]=2)[CH2:5][CH2:6]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 22765982Ethyl 2-[4-(oxan-4-yl)phenoxy]propanoate

생성물 1

HCID 203654662-[4-(Oxan-4-yl)phenoxy]propanoic acid수율 89.3%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

7.6 g of ethyl 2-[p-(4-tetrahydropyranyl)-phenoxy]-propanoate were added to a solution of 17 ml of 2N sodium hydroxide and 100 ml of ethanol and the mixture was stirred for 2 hours at room temperature and then was refluxed for 30 minutes. The mixture was evaporated to dryness and the residue was dissolved in 20 ml of N sodium hydroxide. The solution was washed with ether and acidified with 4N hydrochloric acid. The mixture was filtered and the recovered crystals were washed with water and dried. The product was crystallized from a 50-50 cyclohexane-ethyl acetate mixture to obtain 6.1 g of 2-[p-(4-tetrahydropyranyl)-phenoxy]-propanoic acid melting at 156° C.

후처리

  1. temperaturewas refluxed for 30 minutes
  2. customThe mixture was evaporated to dryness
  3. dissolutionthe residue was dissolved in 20 ml of N sodium hydroxide
  4. washThe solution was washed with ether
  5. filtrationThe mixture was filtered
  6. washthe recovered crystals were washed with water
  7. customdried
  8. customThe product was crystallized from a 50-50 cyclohexane-ethyl acetate mixture

출처 및 근거

ORD 기록
ord-03cd5983ed1f4051a3b5dd1ff1f062f2
출처 데이터셋
uspto-grants-1978_03
특허 번호
US04078076

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