Phenol → Phenyl hexanoate

HRID 1678977노트

반응식

HRID 1678977 반응식
[C:1](Cl)(=[O:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[C:9]1([OH:15])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>N1C=CC=CC=1>[C:1]([O:15][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)(=[O:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

참가 물질

4

반응물 2

HCID 996PhenolHCID 67340Hexanoyl chloride

생성물 1

HCID 522678Phenyl hexanoate수율 94.7%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

30 ml (0.22 mole) of hexanoyl chloride were added dropwise over 30 minutes with stirring and cooling on an ice bath to a solution of 18.8 g (0.2 mole) of phenol in 80 ml of anhydrous pyridine and then the reaction mixture stood at room temperature for 3 hours and was poured into ice water. The mixture was extracted with ether and the ether extracts were washed with water, dilute hydrochloric acid and with water, dried over magnesium sulfate and evaporated to dryness to obtain 36.4 g of phenyl hexanoate as a yellow oil.

후처리

  1. extractionThe mixture was extracted with ether
  2. washthe ether extracts were washed with water, dilute hydrochloric acid and with water
  3. dry with materialdried over magnesium sulfate
  4. customevaporated to dryness

출처 및 근거

ORD 기록
ord-f49c262856cb4177bd41e988fbf8f852
출처 데이터셋
uspto-grants-1978_03
특허 번호
US04078078

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