Hydrochloric Acid → N'-{4-[2-Chloro-4-(trifluoromethyl)phenoxy]phenyl}-N,N-dimethylurea

HRID 1679239

반응식

HRID 1679239 반응식
[CH3:1][N:2]([CH3:6])[C:3](Cl)=[O:4].[Cl:7][C:8]1[CH:21]=[C:20]([C:22]([F:25])([F:24])[F:23])[CH:19]=[CH:18][C:9]=1[O:10][C:11]1[CH:17]=[CH:16][C:14]([NH2:15])=[CH:13][CH:12]=1.O.Cl>N1C=CC=CC=1>[CH3:1][N:2]([CH3:6])[C:3]([NH:15][C:14]1[CH:13]=[CH:12][C:11]([O:10][C:9]2[CH:18]=[CH:19][C:20]([C:22]([F:23])([F:24])[F:25])=[CH:21][C:8]=2[Cl:7])=[CH:17][CH:16]=1)=[O:4]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 6598Dimethylcarbamoyl ChlorideHCID 104693274-[2-Chloro-4-(trifluoromethyl)phenoxy]aniline

생성물 1

HCID 20362098N'-{4-[2-Chloro-4-(trifluoromethyl)phenoxy]phenyl}-N,N-dimethylurea수율 89%

시약·촉매·용매 1

HCID 1049Pyridine용매2회

실험 절차

13 g (0.14 mole) of dimethylcarbamic acid chloride were added dropwise to 29 g (0.1 mole) of 4-(2-chloro-4-trifluoromethyl-phenoxy)-aniline, dissolved in 50 ml of pyridine, at 0° C. The mixture was warmed to 70°-75° C for half an hour, the bulk of the pyridine was stripped off in vacuo and the residue was poured into water and acidified with dilute hydrochloric acid. The precipitate was filtered off, dried and recrystallized from toluene. 29 g (89% of theory) of N,N-dimethyl-N'-[4-(2-chloro-4-trifluoromethylphenoxy)-phenyl]-urea were obtained as pink crystals of melting point 140° C.

후처리

  1. temperatureThe mixture was warmed to 70°-75° C for half an hour
  2. filtrationThe precipitate was filtered off
  3. customdried
  4. customrecrystallized from toluene

출처 및 근거

ORD 기록
ord-5c3a23b6e3d148508c71b1315686de45
출처 데이터셋
uspto-grants-1978_03
특허 번호
US04080193

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