Hydrochloric Acid → HCID 70436618, 화합물

HRID 1679695노트

반응식

HRID 1679695 반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([NH:9][CH:10]1[C:30](=[O:31])[N:12]2[C:13]([C:17]([O:19]CC3C=CC([N+]([O-])=O)=CC=3)=[O:18])=[CH:14][CH2:15][S:16][C@H:11]12)=[O:8].CO.O1CCCC1.Cl>[Pd].O.C(Cl)Cl>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([NH:9][CH:10]1[C:30](=[O:31])[N:12]2[C:13]([C:17]([OH:19])=[O:18])=[CH:14][CH2:15][S:16][C@H:11]12)=[O:8]

참가 물질

8

반응물 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 8028TetrahydrofuranHCID 70617193HCID 70617193, 화합물

생성물 1

HCID 70436618HCID 70436618, 화합물수율 92.1%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 962Water용매2회HCID 6344Dichloromethane용매

실험 절차

To a mixture of p-nitrobenzyl 7-(2-thienyl)acetamido-3-cephem-4-carboxylate (2.0 g), methanol (40 ml), and tetrahydrofuran (40 ml) one adds 10% hydrochloric acid (1.4 ml) and 5% palladium on carbon (1.9 g), shakes the mixture under hydrogen atmosphere (1 atm.) at room temperature for 2.5 hours, pours into water, extracts with methylene chloride, washes with water, dries, concentrates, and crystallizes from ether to give 7-(2-thienyl)acetamido-3-cephem-4-carboxylic acid (1.30 g).

후처리

  1. customat room temperature
  2. customfor 2.5 hours
  3. customcrystallizes from ether

출처 및 근거

ORD 기록
ord-4555acf51ada44adb698a8ba51dc8e7a
출처 데이터셋
uspto-grants-1978_03
특허 번호
US04081595

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