Hydrochloric Acid → HCID 70574841, 화합물

HRID 1680014노트

반응식

HRID 1680014 반응식
[ClH:1].[NH2:2][CH:3]([CH:11]1[NH:15][CH:14]([C:16]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])[C:13]2([CH2:30][CH2:29][N:28]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[CH2:27][CH2:26]2)[S:12]1)[C:4]([O:6]C(C)(C)C)=[O:5]>[N+](C)([O-])=O>[ClH:1].[ClH:1].[NH2:2][CH:3]([CH:11]1[NH:15][CH:14]([C:16]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])[C:13]2([CH2:26][CH2:27][N:28]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[CH2:29][CH2:30]2)[S:12]1)[C:4]([OH:6])=[O:5]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 23458748HCID 23458748, 화합물

생성물 1

HCID 70574841HCID 70574841, 화합물수율 95.5%

시약·촉매·용매 1

HCID 6375Nitromethane용매

실험 절차

A stream of gaseous hydrogen chloride is passed through a suspension of 11 g (0.0206 mole) of tert-butyl alpha-amino-4-benzyloxycarbonyl-8-phenyl-1-thia-3,8-diazaspiro[4.5]decane-2-acetate (obtained in 4.3) in 200 ml of nitromethane. After 1 hour, a clear solution is obtained which is filtered through "Hyflocel" and the filtrate is evaporated to dryness. The residue is taken up in diethyl ether, filtered and washed with diethyl ether. There are obtained 9.4 g of alpha-amino-4-benzyloxycarbonyl-8-phenyl-1-thia-3,8-diazaspiro[4.5]decane-2-acetic acid dihydrochloride. Yield: 95.5%; M.P. 164°-167° C. (decomposition).

후처리

  1. customa clear solution is obtained which
  2. filtrationis filtered through "Hyflocel"
  3. customthe filtrate is evaporated to dryness
  4. filtrationfiltered
  5. washwashed with diethyl ether

출처 및 근거

ORD 기록
ord-32495cf419ef4049971c87f55029ec50
출처 데이터셋
uspto-grants-1981_06
특허 번호
US04271172

반응 노트

불러오는 중…