Hydrochloric Acid → HCID 23457161, 화합물

HRID 1680152노트

반응식

HRID 1680152 반응식
[Cl:1][C:2]1[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[C:3]=1[NH:4][C:5]1[C:6]([CH2:10]O)=[CH:7][S:8][CH:9]=1.[ClH:17]>>[Cl:1][C:2]1[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[C:3]=1[NH:4][C:5]1[C:6]([CH2:10][Cl:17])=[CH:7][S:8][CH:9]=1

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 234571594-(2,6-Dichloroanilino)-3-thiophenemethanol

생성물 1

HCID 23457161HCID 23457161, 화합물

실험 절차

27.4 g (0.1 mole) of 4-(2,6-dichloroanilino)-3-thiophenmethanol are dissolved in 800 ml of concentrated aqueous hydrochloric acid, and the solution is left to stand for eight hours, poured onto ice and extracted with toluene. The organic phase is washed with sodium bicarbonate solution, dried and concentrated. Recrystallization of the residue from petroleum ether gives 3-(2,6-dichloroanilino)-4-chloromethylthiophen (m. 89° to 92°).

후처리

  1. waitthe solution is left
  2. additionpoured onto ice
  3. extractionextracted with toluene
  4. washThe organic phase is washed with sodium bicarbonate solution
  5. customdried
  6. concentrationconcentrated
  7. customRecrystallization of the residue from petroleum ether

출처 및 근거

ORD 기록
ord-16231ea2333b4d1b814177caa6dbfbce
출처 데이터셋
uspto-grants-1981_06
특허 번호
US04272507

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