1-Bromo-3-methylbutane → 15-Methylhexadecyl bromide

HRID 1680301

반응식

HRID 1680301 반응식
[CH3:1][CH:2]([CH3:6])[CH2:3][CH2:4]Br.[Mg:7].[Br:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][Br:21]>[Li+].[Li+].[Cl-].[Cl-].[Cl-].[Cl-].[Cu+2].O1CCCC1>[CH3:1][CH:2]([CH3:6])[CH2:3][CH2:4][Mg:7][Br:8].[CH3:1][CH:2]([CH3:6])[CH2:3][CH2:4][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][Br:21]

참가 물질

7

반응물 3

HCID 78911-Bromo-3-methylbutaneHCID 187661,12-DibromododecaneHCID 5462224Magnesium

생성물 2

HCID 2043738515-Methylhexadecyl bromideHCID 178418529HCID 178418529, 화합물

시약·촉매·용매 2

HCID 193501Copper;dilithium;tetrachloride촉매HCID 8028Tetrahydrofuran용매2회

실험 절차

A solution of 3-methylbutylmagnesium bromide is prepared by treating 15 g. (0.1 mole) 3-methylbutyl bromide with 2.7 g. (1.1 eq) magnesium turnings in 50 ml. dry tetrahydrofuran. The resultant Grignard reagent is dropwise added to a cold (-10° C.) solution of 36.1 g. (1.1 eq) 1,12-dibromododecane and 0.2 g. (1 m mole) dilithiumtetrachloro cuprate in 75 ml. dry tetrahydrofuran. The solution is stirred for one hour, evaporated, and fractionally distilled in vacuo to yield 15-methylhexadecylbromide as a colorless liquid.

후처리

  1. additionby treating 15 g
  2. customevaporated
  3. distillationfractionally distilled in vacuo

출처 및 근거

ORD 기록
ord-e2a90b0c8706459a91b19be9454079b7
출처 데이터셋
uspto-grants-1981_06
특허 번호
US04272546

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