Chloroacetyl chloride → 2-Chloro-1-(2,3,5,6-tetramethylphenyl)ethanone

반응식

[Cl-].[Cl-].[Cl-].[Al+3].[Cl:5][CH2:6][C:7](Cl)=[O:8].[C:10]1([C:12](=[CH:14][C:15](=[C:17]([CH:19]=1)[CH3:18])[CH3:16])[CH3:13])[CH3:11]>>[Cl:5][CH2:6][C:7]([C:19]1[C:17]([CH3:18])=[C:15]([CH3:16])[CH:14]=[C:12]([CH3:13])[C:10]=1[CH3:11])=[O:8]

참가 물질

반응물 3

HCID 6577Chloroacetyl chloride

HCID 7269Durene

HCID 6451240Aluminum(III) Chloride

생성물 1

HCID 24974472-Chloro-1-(2,3,5,6-tetramethylphenyl)ethanone수율 84.6%

실험 절차

Example 1 was repeated but 1.33 g of aluminium trichloride, 1.13 g of chloroacetyl chloride and 1.34 g of durene were employed. 1.78 g of 3-chloroacetyl-durene were obtained, melting point 65.5°=66° C. The product was purified by distillation (bp 113°-117° C.)/0.4 mmHg) and crystallized from ethanol. Similarly, 3-bromoacetyl-durene, melting 53°-54° C. was obtained.

출처 및 근거

ORD 기록: ord-3fc0a73a53984d14841e33a9b0a4e689
출처 데이터셋: uspto-grants-1981_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04275071

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