Water → 1-([1,1'-Biphenyl]-2-yl)-2-bromoethan-1-one

HRID 1680648노트

반응식

HRID 1680648 반응식
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(=[O:3])[CH3:2].[Br:16]Br.O>C(Cl)(Cl)Cl>[Br:16][CH2:2][C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:3]

참가 물질

5

반응물 3

HCID 962WaterHCID 24408BromineHCID 111599031-((1,1'-Biphenyl)-2-yl)ethan-1-one

생성물 1

HCID 127478451-([1,1'-Biphenyl]-2-yl)-2-bromoethan-1-one수율 114.4%

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

To a solution of 1.86 g of 2-acetyl-biphenyl in 10 ml of anhydrous chloroform, a solution of 1.29 g of bromine in 1.5 ml of anhydrous chloroform was added at 15°-20° C. When the addition was complete, the solution was stirred for 15 minutes, then poured into water. The chloroformic solution was washed with sodium bicarbonate and water, dried over calcium chloride and evaporated to dryness. 2.54 g of 2-bromoacetyl-biphenyl were obtained; the product could be used for reaction with imidazole without further purification.

후처리

  1. additionWhen the addition
  2. washThe chloroformic solution was washed with sodium bicarbonate and water
  3. dry with materialdried over calcium chloride
  4. customevaporated to dryness

출처 및 근거

ORD 기록
ord-a69e300dba6442fa9af744af8d077b5f
출처 데이터셋
uspto-grants-1981_06
특허 번호
US04275071

반응 노트

불러오는 중…