Hydrogen Bromide → HCID 23455899, 화합물

HRID 1680707노트

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HRID 1680707 반응식
C(OC([C:6]1[O:7][C:8]2[CH:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][C:19]([CH2:22][C:23]([O:25]CC)=[O:24])=[CH:18][CH:17]=3)=[CH:12][C:9]=2[C:10]=1[CH3:11])=O)C.Br>C(O)(=O)C>[CH3:11][C:10]1[C:9]2[CH:12]=[C:13]([C:16]3[CH:21]=[CH:20][C:19]([CH2:22][C:23]([OH:25])=[O:24])=[CH:18][CH:17]=3)[CH:14]=[CH:15][C:8]=2[O:7][CH:6]=1

참가 물질

4

반응물 2

HCID 260Hydrogen BromideHCID 12902869HCID 12902869, 화합물

생성물 1

HCID 23455899HCID 23455899, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A solution of 17 g. of the product of step A in 100 ml. of acetic acid with 35 ml. of 48 percent hydrobromic acid is heated at reflux for three hours, then poured into ice water. This mixture is extracted into dichloromethane, and the extracts are dried to provide 4-(3-methylbenzofuran-5-yl)phenylacetic acid. This intermediate is esterified by heating with a trace of sulfuric acid in ethanol. The product is purified by chromatography on silica gel, eluting with 20 percent dichloromethane in carbon tetrachloride to provide ethyl 4-(3-methylbenzofuran-5-yl)phenylacetate.

후처리

  1. temperatureat reflux for three hours
  2. extractionThis mixture is extracted into dichloromethane
  3. customthe extracts are dried

출처 및 근거

ORD 기록
ord-0871856f0b9d470db87cbd2c7588c054
출처 데이터셋
uspto-grants-1981_06
특허 번호
US04275221

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