Sodium Hydroxide → 2-[(4-Methoxyphenoxy)methyl]-4(3H)-pteridinone

HRID 1681041노트

반응식

HRID 1681041 반응식
N[C:2]1[C:11]2[C:6](=[N:7][CH:8]=[CH:9][N:10]=2)[N:5]=[C:4]([CH2:12][O:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)[N:3]=1.[OH-:22].[Na+]>>[CH3:21][O:20][C:17]1[CH:18]=[CH:19][C:14]([O:13][CH2:12][C:4]2[NH:3][C:2](=[O:22])[C:11]3[C:6](=[N:7][CH:8]=[CH:9][N:10]=3)[N:5]=2)=[CH:15][CH:16]=1

참가 물질

3

반응물 2

HCID 14798Sodium HydroxideHCID 10731668HCID 10731668, 화합물

생성물 1

HCID 1355138312-[(4-Methoxyphenoxy)methyl]-4(3H)-pteridinone

실험 절차

Obtained using the procedure described in section b of Example 9, starting with 5.5 g (0.0194 mole) of 4-amino-2-[(4-methoxyphenoxy)methyl]pteridine in 150 ml of 5% aqueous sodium hydroxide. The solid obtained is taken up in dilute sodium hydroxide for purification. The insoluble portion is removed by filtration. The filtrate is acidified with acetic acid to pH 5.5. The precipitate formed is isolated by filtration; it is finally recrystallized from a mixture of ethanol and N,N-dimethylformamaide. Yld: 1.7 g (31%), m.p. 233°-234° C.

후처리

  1. customObtained
  2. customThe solid obtained
  3. customis taken up in dilute sodium hydroxide for purification
  4. customThe insoluble portion is removed by filtration
  5. customThe precipitate formed
  6. customis isolated by filtration
  7. customit is finally recrystallized from a mixture of ethanol and N,N-dimethylformamaide

출처 및 근거

ORD 기록
ord-d6db59a18fc848248c0bf7e695ba9520
출처 데이터셋
uspto-grants-1992_12
특허 번호
US05167949

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