Phosphorus tribromide → 4-Bromo-2,6-bis(trifluoromethyl)pyridine

HRID 1681200노트

반응식

HRID 1681200 반응식
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:8]=[C:7](O)[CH:6]=[C:5]([C:10]([F:13])([F:12])[F:11])[N:4]=1.P(Br)(Br)[Br:17]>C(Cl)Cl>[Br:17][C:7]1[CH:8]=[C:3]([C:2]([F:15])([F:14])[F:1])[N:4]=[C:5]([C:10]([F:13])([F:12])[F:11])[CH:6]=1

참가 물질

4

반응물 2

HCID 24614Phosphorus tribromideHCID 178516142HCID 178516142, 화합물

생성물 1

HCID 150303204-Bromo-2,6-bis(trifluoromethyl)pyridine

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A mixture of 6 g 2,6-di(trifluoromethyl)-4-hydroxypyridine and 4.9 ml phosphorus tribromide was heated 15 min. at 140°-150° C. and 90 min. at 160°-170° C. The reaction mixture was cooled, 150 ml methylene dichloride added, and poured into ice-water. From the methylene dichloride layer there was isolated 3.5 g 4-bromo-2,6-di(trifluoromethyl)pyridine, colorless solid, m.p. 92°-95° C.

후처리

  1. temperaturewas heated 15 min. at 140°-150° C. and 90 min. at 160°-170° C
  2. temperatureThe reaction mixture was cooled

출처 및 근거

ORD 기록
ord-405f2910cbf24edeb607b63099879c79
출처 데이터셋
uspto-grants-1992_12
특허 번호
US05169853

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