Styrene Oxide → alpha-[[[2-(Phenylmethoxy)propyl]amino]methyl]benzenemethanol

HRID 1681349

반응식

HRID 1681349 반응식
[CH2:1]1[O:9][CH:2]1[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH2:10]([O:17][CH:18]([CH3:21])[CH2:19][NH2:20])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[C:11]1([CH2:10][O:17][CH:18]([CH3:21])[CH2:19][NH:20][CH2:1][CH:2]([C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=2)[OH:9])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

3

반응물 2

HCID 7276Styrene OxideHCID 2960152-(Benzyloxy)propan-1-amine

생성물 1

HCID 19806395alpha-[[[2-(Phenylmethoxy)propyl]amino]methyl]benzenemethanol수율 84.1%

반응 조건

온도
140 °C

실험 절차

A mixture of styrene oxide (1.96 g, 0.010 mol) and 2-benzyloxypropylamine (2.48 g, 0.15 mol) was heated at 140° C. for 6 hours and then allowed to cool to ambient temperature and stand for 12 hours. The solidified reaction mixture was triturated with isooctane and filtered to obtain an impure solid that was recrystallized from isooctane to obtain 2.40 g of a white solid (84% yield); mp 90°-100° C. (undefined).

후처리

  1. temperatureto cool to ambient temperature
  2. customThe solidified reaction mixture
  3. customwas triturated with isooctane
  4. filtrationfiltered
  5. customto obtain an impure solid
  6. customthat was recrystallized from isooctane

출처 및 근거

ORD 기록
ord-9930972b977f40ce97126d92214321de
출처 데이터셋
uspto-grants-1992_12
특허 번호
US05171753

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