Hydrochloric Acid → 4-((Dimethylamino)methyl)-4-piperidinol dihydrochloride

반응식

[CH3:1][N:2]([CH2:4][C:5]1([OH:16])[CH2:10][CH2:9][N:8](C(OCC)=O)[CH2:7][CH2:6]1)[CH3:3].[ClH:17]>>[ClH:17].[ClH:17].[CH3:3][N:2]([CH2:4][C:5]1([OH:16])[CH2:6][CH2:7][NH:8][CH2:9][CH2:10]1)[CH3:1]

참가 물질

반응물 2

HCID 313Hydrochloric Acid

HCID 19382159HCID 19382159, 화합물

생성물 1

HCID 193822164-((Dimethylamino)methyl)-4-piperidinol dihydrochloride

실험 절차

4.5 g (19.4 mmol) of ethyl 4-dimethylaminomethyl-4-hydroxypiperidine-1-carboxylate are heated overnight under reflux with 35 ml of concentrated hydrochloric acid. The product is concentrated, and the crystals are triturated with acetone, filtered off with suction and dried in a vacuum desiccator over P4O10.

후처리

concentrationThe product is concentrated
customthe crystals are triturated with acetone
filtrationfiltered off with suction
dry with materialdried in a vacuum desiccator over P4O10

출처 및 근거

ORD 기록: ord-9751c57246f043a7b0ae33d318e7a896
출처 데이터셋: uspto-grants-1992_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05173484

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