Hydrochloric Acid → 4-(Pyridin-2-yl)piperidine-4-carbonitrile hydrochloride

HRID 1683008노트

반응식

HRID 1683008 반응식
C(OC([N:8]1[CH2:13][CH2:12][C:11]([C:20]#[N:21])([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22].O1CCOCC1>>[ClH:22].[C:20]([C:11]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=2)[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)#[N:21]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 53439111Tert-butyl 4-cyano-4-(pyridin-2-YL)piperidine-1-carboxylate

생성물 1

HCID 673222724-(Pyridin-2-yl)piperidine-4-carbonitrile hydrochloride

실험 절차

Prepare by the method of example 30.3 using 1-tert-butoxycarbonyl-4-cyano-4-(pyridin-2-yl)-piperidine (3 mmol) and HCl in dioxane (40 mmol, 4N). Concentrate the solvent in vacuo and dry under high vacuum to give the title compound.

후처리

  1. concentrationConcentrate the solvent in vacuo
  2. customdry under high vacuum

출처 및 근거

ORD 기록
ord-ff7271a5c2654dbe9c2463f023de724e
출처 데이터셋
uspto-grants-1997_06
특허 번호
US05635510

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