Acetic Acid → 4,5,6,7-Tetrahydro-2-benzimidazolone
반응식
Br[CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C:3]1=O.[NH2:9][C:10]([NH2:12])=[O:11].C([O-])(=O)C.[NH4+].C(O)(=O)C>O>[N:9]1[C:10](=[O:11])[N:12]=[C:2]2[CH2:7][CH2:6][CH2:5][CH2:4][C:3]=12참가 물질
6
실험 절차
A mixture of 2-bromocyclohexanone (6.23 g, 0.035 mol) and urea (2.1 g, 0.035 mol) is refluxed in a solution of ammonium acetate (10 g), acetic acid (15 mL) and water (50 mL) for 4 h. Upon cooling slowly to room temp, white crystals form in the reaction vessel. The solid is collected by suction filtration, washed thoroughly with water and ether, and dried in vacuo to afford 4,5,6,7-tetrahydro-2-benzimidazolone (Compound 7).
후처리
- filtrationThe solid is collected by suction filtration
- washwashed thoroughly with water and ether
- customdried in vacuo
출처 및 근거
- ORD 기록
- ord-4314b798c9844be48a37a26ffe395954
- 출처 데이터셋
- uspto-grants-1997_06
- 특허 번호
- US05637725
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