Water → 4-(2-Fluorophenyl)butanenitrile
반응식
[O-][C:2]#[N:3].[Na+].S(C1C=CC(C)=CC=1)(O[CH2:9][CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[F:18])(=O)=O.O>CS(C)=O>[F:18][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[CH2:11][CH2:10][CH2:9][C:2]#[N:3]참가 물질
5
실험 절차
To a solution of 9.89 gm of sodium cyanate in 35 ml of dimethylsulfoxide (hereinafter abbreviated as DMSO) was added dropwise a solution of 31.2 gm of the compound prepared in (4) above in 70 ml of DMSO. The mixture was stirred for 12 hours at room temperature. After the addition of 500 ml of water, the mixture was extracted twice with 200 ml of ether. The extract was washed with water and saturated brine in this order, and dried over anhydrous sodium sulfate. The solvent was evaporated to obtain 15.4 gm of the title compound.
후처리
- extractionthe mixture was extracted twice with 200 ml of ether
- washThe extract was washed with water and saturated brine in this order
- dry with materialdried over anhydrous sodium sulfate
- customThe solvent was evaporated
출처 및 근거
- ORD 기록
- ord-879b2ecbbd2f490a9c828e4e7f1b3042
- 출처 데이터셋
- uspto-grants-1997_06
- 특허 번호
- US05637770
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