Sulfuric acid magnesium salt (1:1) → 8-Acetylamino-5,6-difluoro-1-tetralone

HRID 1683499노트

반응식

HRID 1683499 반응식
[C:1]([NH:4][C:5]1[CH:14]=[C:13]([F:15])[C:12]([F:16])=[C:11]2[C:6]=1[CH2:7][CH2:8][CH2:9][CH2:10]2)(=[O:3])[CH3:2].S([O-])([O-])(=O)=[O:18].[Mg+2].[Mn]([O-])(=O)(=O)=O.[K+]>CC(C)=O>[C:1]([NH:4][C:5]1[CH:14]=[C:13]([F:15])[C:12]([F:16])=[C:11]2[C:6]=1[C:7](=[O:18])[CH2:8][CH2:9][CH2:10]2)(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 24083Sulfuric acid magnesium salt (1:1)HCID 516875Potassium PermanganateHCID 10609230HCID 10609230, 화합물

생성물 1

HCID 224495258-Acetylamino-5,6-difluoro-1-tetralone

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of the compound obtained in (6) above (810 mg) in 30 ml of acetone was added 3 ml of 15% aqueous solution of magnesium sulfate. 1.17 gm of potassium permanganate was slowly added to the mixture while stirring. After 1 hour, the reaction product was extracted with chloroform, the extract was washed with water and saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated to obtain 806 mg of the title compound.

후처리

  1. extractionthe reaction product was extracted with chloroform
  2. washthe extract was washed with water and saturated brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-e6a6e1968e274e2789e4ed93ccd663d2
출처 데이터셋
uspto-grants-1997_06
특허 번호
US05637770

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