N-bromobutanimide → 3,7-Dibromo-2,3-dihydro-2,2-dimethylbenzofuran

HRID 1683686

반응식

HRID 1683686 반응식
[Br:1][C:2]1[C:10]2[O:9][C:8]([CH3:12])([CH3:11])[CH2:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[Br:13]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl>[Br:13][CH:7]1[C:6]2[CH:5]=[CH:4][CH:3]=[C:2]([Br:1])[C:10]=2[O:9][C:8]1([CH3:12])[CH3:11]

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 2720047-Bromo-2,2-dimethyl-2,3-dihydro-1-benzofuran

생성물 1

HCID 190407783,7-Dibromo-2,3-dihydro-2,2-dimethylbenzofuran

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

A stirring mixture of 7.0 grams (0.031 mole) of 7-bromo-2,3-dihydro-2,2-dimethylbenzofuran and 5.5 grams (0.031 mole) of N-bromosuccinimide in 150 mL of carbon tetrachloride is heated to reflux while irradiating with a sun lamp. The refluxing reaction mixture is stirred for about three hours, then it is cooled to ambient temperature. After this time the reaction mixture is washed with two 50 mL portions of aqueous 5% sodium bicarbonate solution, and one 50 mL portion of water. The organic layer is dried with magnesium sulfate and filtered. The filtrate is concentrated under reduced pressure, yielding 3,7-dibromo-2,3-dihydro-2,2-dimethylbenzofuran.

후처리

  1. temperatureis heated
  2. temperatureto reflux
  3. customwhile irradiating with a sun lamp
  4. customThe refluxing reaction mixture
  5. washAfter this time the reaction mixture is washed with two 50 mL portions of aqueous 5% sodium bicarbonate solution, and one 50 mL portion of water
  6. dry with materialThe organic layer is dried with magnesium sulfate
  7. filtrationfiltered
  8. concentrationThe filtrate is concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-f9377cadf7c145cfbdf166638de5c4b4
출처 데이터셋
uspto-grants-1997_06
특허 번호
US05639753

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