Potassium Acetate → 3-Acetoxy-7-bromo-2,3-dihydro-2,2-dimethylbenzofuran

HRID 1683687

반응식

HRID 1683687 반응식
Br[CH:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([Br:11])[C:5]=2[O:4][C:3]1([CH3:13])[CH3:12].[C:14]([O-:17])(=[O:16])[CH3:15].[K+]>CN(C)C=O>[C:14]([O:17][CH:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([Br:11])[C:5]=2[O:4][C:3]1([CH3:13])[CH3:12])(=[O:16])[CH3:15]

참가 물질

4

반응물 2

HCID 517044Potassium AcetateHCID 190407783,7-Dibromo-2,3-dihydro-2,2-dimethylbenzofuran

생성물 1

HCID 190407903-Acetoxy-7-bromo-2,3-dihydro-2,2-dimethylbenzofuran

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 7.6 grams (0.025 mole) of 3,7-dibromo-2,3-dihydro-2,2-dimethylbenzofuran and 11.3 grams (0.115 mole) of powdered potassium acetate in 125 mL of dry N,N-dimethylformamide is stirred at ambient temperature for about 24 hours. After this time, the reaction mixture is concentrated under reduced pressure to a residue. The residue is poured into about 350 mL of water and the mixture is extracted with diethyl ether. The ether extract is concentrated under reduced pressure, yielding 3-acetoxy-7-bromo-2,3-dihydro-2,2-dimethylbenzofuran.

후처리

  1. concentrationAfter this time, the reaction mixture is concentrated under reduced pressure to a residue
  2. additionThe residue is poured into about 350 mL of water
  3. extractionthe mixture is extracted with diethyl ether
  4. extractionThe ether extract
  5. concentrationis concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-b440da6bf18c4451bca4470adaae49ee
출처 데이터셋
uspto-grants-1997_06
특허 번호
US05639753

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