Hydrazine hydrate (1:1) → 5-(4-Chloro-phenyl)-2,4-dihydro-pyrazol-3-one

HRID 1683810노트

반응식

HRID 1683810 반응식
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([C:6]([C:8](C)(C)[C:9](OCC)=[O:10])=O)=[CH:4][CH:3]=1.O.[NH2:19][NH2:20]>C(O)C>[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([C:6]2[CH2:8][C:9](=[O:10])[NH:20][N:19]=2)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 16638375HCID 16638375, 화합물

생성물 1

HCID 47787935-(4-Chloro-phenyl)-2,4-dihydro-pyrazol-3-one수율 82,212.5%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 26 g (0.10 mmol) of ethyl α-(4-chlorobenzoyl)isobutyrate, 10 g (0.20 mmol) of hydrazine monohydrate and 200 ml of ethanol was heated under reflux for 18 hours. The reaction solution was concentrated under reduced pressure. The obtained crude product was washed successively with water, methanol-water and diethyl ether-n-hexane, and then air dried to give 16 g of the object compound as white crystals (yield 84%).

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 18 hours
  3. concentrationThe reaction solution was concentrated under reduced pressure
  4. customThe obtained crude product
  5. washwas washed successively with water, methanol-water and diethyl ether-n-hexane
  6. customair dried

출처 및 근거

ORD 기록
ord-5449332995294ab599caac6f51e011c8
출처 데이터셋
uspto-grants-1997_06
특허 번호
US05639776

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