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Sodium Carbonate → HCID 178475053, 화합물

HRID 1683939
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HRID 1683939 반응식
Cl.[NH2:2][OH:3].C(=O)([O-])[O-].[Na+].[Na+].[C:10]([NH:13][C@H:14]1[C@H:22]([C@@H:23]([C@@H:25]([CH2:27][OH:28])[OH:26])[OH:24])[O:21][C:17]([C:18]([OH:20])=[O:19])=[CH:16][C@@H:15]1[NH:29][C:30]#[N:31])(=[O:12])[CH3:11]>CO>[C:10]([NH:13][C@H:14]1[C@H:22]([C@@H:23]([C@@H:25]([CH2:27][OH:28])[OH:26])[OH:24])[O:21][C:17]([C:18]([OH:20])=[O:19])=[CH:16][C@@H:15]1[NH:29][C:30]([NH2:31])=[N:2][OH:3])(=[O:12])[CH3:11]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 10340Sodium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 9995821HCID 9995821, 화합물

생성물 1

HCID 178475053HCID 178475053, 화합물수율 32.6%

시약·촉매·용매 1

HCID 887Methanol용매

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온도
21 °C

실험 절차

Hydroxylamine hydrochloride (1.1 g, 15.85 mmol)(dried under vacuum over P2O5) was dissolved in dried (over 3 A mol. sieves) methanol (20 ml) and sodium carbonate (0.835 g, 7.9 mmol) was added. This was stirred at 21° C. under N2 for 15 min., then solid was filtered off. To the filtrate was then added the product of Example 1, step (i) (500 mg, 1.585 mmol) and stirring under N2 at 21° C. continued for 16 hr. White solid was filtered off, air dried, then dried under high vacuum to give the title compound (Yield, 180 mg).

후처리

  1. customin dried (over 3 A mol
  2. filtrationsolid was filtered off
  3. stirringstirring under N2 at 21° C.
  4. waitcontinued for 16 hr
  5. filtrationWhite solid was filtered off
  6. customair dried
  7. customdried under high vacuum

출처 및 근거

ORD 기록
ord-960aba67ac4e4d4780cd3cd5cf5d0661
출처 데이터셋
uspto-grants-1997_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05639786

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