Hydrochloric Acid → [2-(1-(4-Bromobenzyl)-5-methoxy-2-methyl-1H-indol-3-yl) phenyl]methanol

HRID 1684004노트

반응식

HRID 1684004 반응식
[Br:1][C:2]1[CH:29]=[CH:28][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([O:16][CH3:17])=[CH:13][CH:14]=3)[C:9]([C:18]3[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=3[C:20](O)=[O:21])=[C:8]2[CH3:27])=[CH:4][CH:3]=1.S(C)C.Cl.C(OCC)(=O)C>C1COCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([O:16][CH3:17])=[CH:13][CH:14]=3)[C:9]([C:18]3[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=3[CH2:20][OH:21])=[C:8]2[CH3:27])=[CH:28][CH:29]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 1068Dimethyl SulfideHCID 8857Ethyl AcetateHCID 538358182-(1-(4-Bromobenzyl)-5-methoxy-2-methyl-1 H-indol-3-yl) benzoic acid

생성물 1

HCID 53681185[2-(1-(4-Bromobenzyl)-5-methoxy-2-methyl-1H-indol-3-yl) phenyl]methanol수율 99%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of the acid from Step 1 (300 mg, 0.66 mmol) and BH3 Σ SMe2 (0.1 mL, 1 mmol) in THF (3 mL) was gently refluxed for 2 h. The cooled mixture was poured over icy dilute HCl and ethyl acetate. The organic layer was washed with brine and dried with MgSO4. Removal of the solvents yielded essentially pure product (285 mg).

후처리

  1. washThe organic layer was washed with brine
  2. dry with materialdried with MgSO4
  3. customRemoval of the solvents

출처 및 근거

ORD 기록
ord-25e6c5aab31546c49772fa68aa7db7e3
출처 데이터셋
uspto-grants-1997_06
특허 번호
US05639780

반응 노트

불러오는 중…