Hydrochloric Acid → (R)-8-Fluoro-5-hydroxy-3-(N-3-pentyl-N-n-propylamino)chroman hydrochloride

HRID 1684738노트

반응식

HRID 1684738 반응식
[F:1][C:2]1[CH:3]=[CH:4][C:5]([OH:21])=[C:6]2[C:11]=1[O:10][CH2:9][C@H:8]([N:12]([CH:16]([CH2:19][CH3:20])[CH2:17][CH3:18])[CH2:13][CH2:14][CH3:15])[CH2:7]2.[ClH:22]>CCOCC>[ClH:22].[F:1][C:2]1[CH:3]=[CH:4][C:5]([OH:21])=[C:6]2[C:11]=1[O:10][CH2:9][C@H:8]([N:12]([CH:16]([CH2:17][CH3:18])[CH2:19][CH3:20])[CH2:13][CH2:14][CH3:15])[CH2:7]2

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 53847727HCID 53847727, 화합물

생성물 1

HCID 67703430(R)-8-Fluoro-5-hydroxy-3-(N-3-pentyl-N-n-propylamino)chroman hydrochloride

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

(R)-8-Fluoro-5-hydroxy-3-(N-3-pentyl-N-n-propylamino)chroman (180 mg, 0.6 mmol) was dissolved in ether. HCl in ether was added to precipitate the HCl-salt, and gave after drying 200 mg of (R)-8-fluoro-5-hydroxy-3-(N-3-pentyl-N-n-propylamino)chroman hydrochloride as a white powder. Mp: 80°-100° C. (sinters).

후처리

  1. customto precipitate the HCl-salt
  2. customgave
  3. dry with materialafter drying 200 mg of (R)-8-fluoro-5-hydroxy-3-(N-3-pentyl-N-n-propylamino)chroman hydrochloride as a white powder

출처 및 근거

ORD 기록
ord-604e6b33c7b246bd8a5a2fc09ebce22b
출처 데이터셋
uspto-grants-1997_06
특허 번호
US05641807

반응 노트

불러오는 중…