Sodium borohydride → {3-[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl]-2-fluorophenyl}methanol

HRID 1684908노트

반응식

HRID 1684908 반응식
[BH4-].[Na+].[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]3[CH:17]=[CH:16][C:15]([C:18]4[C:19]([F:26])=[C:20]([CH:23]=[CH:24][CH:25]=4)[CH:21]=[O:22])=[CH:14][N:13]3[CH:27]=2)=[CH:6][CH:5]=1>CO>[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]3[CH:17]=[CH:16][C:15]([C:18]4[C:19]([F:26])=[C:20]([CH2:21][OH:22])[CH:23]=[CH:24][CH:25]=4)=[CH:14][N:13]3[CH:27]=2)=[CH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 86651935HCID 86651935, 화합물

생성물 1

HCID 44231745{3-[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl]-2-fluorophenyl}methanol수율 57.7%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

162 mg of sodium borohydride are added portionwise to 150 mg of 3-[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]-2-fluorobenzaldehyde dissolved in 20 ml of methanol. The mixture is subsequently stirred at ambient temperature for 2 hours and then the solvent is evaporated under reduced pressure. The residue is taken up between water and dichloromethane and the organic phase is separated, dried over sodium sulphate and evaporated under reduced pressure. The residue is purified by chromatography on silica gel, elution being carried out with a dichloromethane/methanol 98/02 mixture. 87 mg of compound are obtained.

후처리

  1. customthe solvent is evaporated under reduced pressure
  2. customthe organic phase is separated
  3. dry with materialdried over sodium sulphate
  4. customevaporated under reduced pressure
  5. customThe residue is purified by chromatography on silica gel, elution

출처 및 근거

ORD 기록
ord-6f275abcd02440a383bcc838b6fa7230
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08148370B2

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