Sodium borohydride → 3-Bromo-2-fluorobenzyl Alcohol

HRID 1684918

반응식

HRID 1684918 반응식
[Br:1][C:2]1[C:3]([F:10])=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6].[BH4-].[Na+]>CO>[Br:1][C:2]1[C:3]([F:10])=[C:4]([CH2:5][OH:6])[CH:7]=[CH:8][CH:9]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 220193613-Bromo-2-fluorobenzaldehyde

생성물 1

HCID 269856463-Bromo-2-fluorobenzyl Alcohol수율 77.2%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2.00 g of 3-bromo-2-fluorobenzaldehyde are dissolved in 98 ml of methanol; 560 mg of sodium borohydride are added portionwise thereto. The mixture is stirred at ambient temperature for 2 hours and then the solvent is evaporated under reduced pressure. The residue is taken up between water and ethyl acetate and the organic phase is separated, dried and concentrated under reduced pressure. The residue is purified by chromatography on silica gel, elution being carried out with a dichloromethane/methanol mixture. 1.56 g of compound are obtained.

후처리

  1. customthe solvent is evaporated under reduced pressure
  2. customthe organic phase is separated
  3. customdried
  4. concentrationconcentrated under reduced pressure
  5. customThe residue is purified by chromatography on silica gel, elution

출처 및 근거

ORD 기록
ord-353e33ce6a734bccb2cc1491d02fb782
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08148370B2

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