Sodium borohydride → (2-Bromo-6-fluorophenyl)methanol

HRID 1684924노트

반응식

HRID 1684924 반응식
[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[CH:4]=[O:5].[BH4-].[Na+]>CO>[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[CH2:4][OH:5]

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 224739772-Bromo-6-fluorobenzaldehyde

생성물 1

HCID 44181801(2-Bromo-6-fluorophenyl)methanol수율 90.1%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

20.0 g (0.098 mol) of 2-bromo-6-fluorobenzaldehyde are dissolved in 500 ml of methanol and cooled in an ice bath; 3.72 g (0.098 mol) of sodium borohydride are then added portionwise thereto. The mixture is stirred under cold conditions for 1 hour and then the solid is evaporated under reduced pressure. The residue is taken up between water and dichloromethane and the organic phase is separated, dried and concentrated under reduced pressure. The residue is crystallised from pentane. 18.1 g of compound are obtained.

후처리

  1. temperaturecooled in an ice bath
  2. customthe solid is evaporated under reduced pressure
  3. customthe organic phase is separated
  4. customdried
  5. concentrationconcentrated under reduced pressure
  6. customThe residue is crystallised from pentane

출처 및 근거

ORD 기록
ord-ca4daeefeadc4e0284d05a297a0deaf5
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08148370B2

반응 노트

불러오는 중…