Ethanol → Acetic acid 2-amino-thiazol-4-ylmethyl ester

HRID 1685052노트

반응식

HRID 1685052 반응식
Cl[CH2:2][C:3](=O)[CH2:4][OH:5].[NH2:7][C:8]([NH2:10])=[S:9].[CH3:11][CH2:12][OH:13]>>[NH2:7][C:8]1[S:9][CH:2]=[C:3]([CH2:4][O:5][C:12](=[O:13])[CH3:11])[N:10]=1

참가 물질

4

반응물 3

HCID 702EthanolHCID 904941-Chloro-3-hydroxy-2-propanoneHCID 2723790Thiourea

생성물 1

HCID 21915033Acetic acid 2-amino-thiazol-4-ylmethyl ester

실험 절차

1-Chloro-3-hydroxy-propan-2-one (15.06 g) and thiourea (8.36 g) were dissolved in EtOH (55 mL) and heated at reflux over 30 min. The reaction mixture was concentrated under reduced pressure to afford the desired product.

후처리

  1. temperatureheated
  2. temperatureat reflux over 30 min
  3. concentrationThe reaction mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-fa3d1f2b4e6948d5999f82786c304316
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08148380B2

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