Chloroacetonitrile → HCID 44542641, 화합물

HRID 1685097노트

반응식

HRID 1685097 반응식
[NH2:1][C:2]1[C:3]2[CH:14]=[C:13]([Br:15])[CH:12]=[CH:11][C:4]=2[S:5][C:6]=1[C:7]([O:9][CH3:10])=[O:8].[Cl:16][CH2:17][C:18]#[N:19]>Cl.O1CCOCC1>[NH2:19][C:18](=[N:1][C:2]1[C:3]2[CH:14]=[C:13]([Br:15])[CH:12]=[CH:11][C:4]=2[S:5][C:6]=1[C:7]([O:9][CH3:10])=[O:8])[CH2:17][Cl:16]

참가 물질

5

반응물 2

HCID 7856ChloroacetonitrileHCID 44542789Methyl 3-amino-5-bromo-1-benzothiophene-2-carboxylate

생성물 1

HCID 44542641HCID 44542641, 화합물

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 312751,4-Dioxane용매

실험 절차

A suspension of EXAMPLE 1A (7.2 g, 25.16 mmol) in 4N hydrochloric acid in dioxane (70 mL) was treated with 2-chloroacetonitrile (3.18 mL, 50.32 mmol) at ambient temperature for 3 hours. The white solid was collected by filtration and dried to give the title compound as the hydrochloride salt. LCMS (APCI) m/z: 362(M+H)+.

후처리

  1. filtrationThe white solid was collected by filtration
  2. customdried

출처 및 근거

ORD 기록
ord-f5122d728e384fb5b448e893fe3bb9a7
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08148384B2

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