Tetrahydrofuran → HCID 14518099, 화합물

HRID 1685181노트

반응식

ClC1[N:7]=[CH:6][N:5]=[C:4]([NH2:8])[C:3]=1[NH:9][CH3:10].Cl[C:12]([Cl:22])(OC(=O)OC(Cl)(Cl)Cl)Cl.C1C[O:26][CH2:25]C1>>[Cl:22][C:12]1[N:7]=[CH:6][N:5]=[C:4]2[C:3]=1[N:9]([CH3:10])[C:25](=[O:26])[NH:8]2

참가 물질

반응물 3

HCID 8028Tetrahydrofuran

HCID 94429Triphosgene

HCID 86641607HCID 86641607, 화합물

생성물 1

HCID 14518099HCID 14518099, 화합물수율 42%

반응 조건

온도: 0 °C

실험 절차

Add 6-chloro-N5-methyl-pyrimidine-4,5-diamine (0.41 g, 0.0025 mol) to THF (12.3 mL). Cool to 0° C., add TEA (0.51 g; 0.005 mol), triphosgene (0.92 g; 0.0031 mol) and stir at RT for 1 h. Quench with water and extract with EA. Evaporate the organic layer to give the title compound (0.2 g; 42%).

후처리

customQuench with water
extractionextract with EA
customEvaporate the organic layer

출처 및 근거

ORD 기록: ord-049592ae6d0d46088b0eb8f4e8e83444
출처 데이터셋: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08148387B2

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