Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Normeperidine → 1-[1-(2-chloro-phenyl)-5-(4-chloro-phenyl)-4-methyl-1H-pyrazole-3-carbonyl]-4-phenyl-piperidine-4-carboxylic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Normeperidine | HCID 32414 | — |
| 반응물 | 2-(1-(2-chlorophenyl)-5-(4-chlorophenyl)-3-(4-phenylpiperazine-1-carbonyl)-1H-pyrazol-4-yl)acetonitrile | HCID 46225108 | — |
| 반응물 | Ethyl 1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-methyl-1h-pyrazole-3-carboxylate | HCID 58760952 | — |
| 생성물 | 1-[1-(2-chloro-phenyl)-5-(4-chloro-phenyl)-4-methyl-1H-pyrazole-3-carbonyl]-4-phenyl-piperidine-4-carboxylic acid ethyl ester | HCID 67265287 | — |
반응 단계
The ester compound [A1] was hydrolysed according to the procedure for the last step in the synthesis of [1.1]. The resulting acid was coupled with 4-phenyl-piperidine-4-carboxylic acid ethyl ester according to the procedure for the synthesis of [C1] to give 1-[1-(2-chloro-phenyl)-5-(4-chloro-phenyl)-4-methyl-1H-pyrazole-3-carbonyl]-4-phenyl-piperidine-4-carboxylic acid ethyl ester.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08148404B2 |
| 출처 데이터셋 | uspto-grants-2012_04 |
| ORD ID | ord-cc46028c9688454bb90018034e64b995 |
| 출처 메모 | uspto-grants-2012_04 |