HRID1685398

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID32414

Normeperidine

C14H19NO2

结构：N#CCc1c(C(=O)N2CCN(c3ccccc3)CC2)nn(-c2ccccc2Cl)c1-c1ccc(Cl)cc1

HCID46225108

未命名化合物

结构：CCOC(=O)c1nn(-c2ccccc2Cl)c(-c2ccc(Cl)cc2)c1C

HCID58760952

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)C1(c2ccccc2)CCN(C(=O)c2nn(-c3ccccc3Cl)c(-c3ccc(Cl)cc3)c2C)CC1

HCID67265287

未命名化合物

PROCEDURE

实验过程

The ester compound [A1] was hydrolysed according to the procedure for the last step in the synthesis of [1.1]. The resulting acid was coupled with 4-phenyl-piperidine-4-carboxylic acid ethyl ester according to the procedure for the synthesis of [C1] to give 1-[1-(2-chloro-phenyl)-5-(4-chloro-phenyl)-4-methyl-1H-pyrazole-3-carbonyl]-4-phenyl-piperidine-4-carboxylic acid ethyl ester.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-cc46028c9688454bb90018034e64b995
来源数据集: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08148404B2
来源说明: uspto-grants-2012_04

反应 SMILES

C(O[C:4]([C:6]1[C:10]([CH3:11])=[C:9]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[N:8]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[Cl:25])[N:7]=1)=[O:5])C.[CH2:26]([O:28][C:29]([C:31]1([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1)=[O:30])[CH3:27].ClC1C=CC(C2N(C3C=CC=CC=3Cl)N=C(C(N3CCN(C4C=CC=CC=4)CC3)=O)C=2CC#N)=CC=1>>[CH2:26]([O:28][C:29]([C:31]1([C:37]2[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=2)[CH2:32][CH2:33][N:34]([C:4]([C:6]2[C:10]([CH3:11])=[C:9]([C:12]3[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=3)[N:8]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[Cl:25])[N:7]=2)=[O:5])[CH2:35][CH2:36]1)=[O:30])[CH3:27]