Anthranilamide → HCID 57737846, 화합물

HRID 1685486노트

반응식

HRID 1685486 반응식
[Br:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([OH:9])=O)[N:6]=1.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.[NH2:34][C:35]1[CH:43]=[CH:42][CH:41]=[CH:40][C:36]=1[C:37]([NH2:39])=[O:38].C(N(CC)C(C)C)(C)C>CN(C)C=O>[NH2:39][C:37]([C:36]1[CH:40]=[CH:41][CH:42]=[CH:43][C:35]=1[NH:34][C:7]([C:5]1[N:6]=[C:2]([Br:1])[S:3][CH:4]=1)=[O:9])=[O:38]

참가 물질

6

반응물 4

HCID 6942AnthranilamideHCID 81531DiisopropylethylamineHCID 27632092-Bromo-1,3-thiazole-4-carboxylic acidHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

생성물 1

HCID 57737846HCID 57737846, 화합물수율 89.9%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

2-Bromo-4-thiazolecarboxylic acid (1 g), HATU (2.01 g) and 2-aminobenzamide (0.65 g) are introduced into N,N-dimethylformamide (DMF) (20 ml). The mixture is cooled with an ice bath, and N,N-diisopropylethylamine (0.90 ml) is added. The reaction mixture is stirred at room temperature for 6 days, poured into ice-water and allowed to thaw with stirring, and the precipitated solid is filtered off with suction, washed twice with water, twice with diethyl ether and dried in vacuo. Intermediate VI.1 is obtained as a solid (1.4 g).

후처리

  1. temperatureThe mixture is cooled with an ice bath
  2. stirringwith stirring
  3. filtrationthe precipitated solid is filtered off with suction
  4. washwashed twice with water, twice with diethyl ether
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-0b89876f04ad4d0392c42ba2c28c30d4
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08148411B2

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