Sodium Hydroxide → 3-(2-Ethyl-4-[5-(4-ethyl-5-formyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenyl}-propionic acid

HRID 1685748

반응식

HRID 1685748 반응식
[OH-].[Na+].[CH2:3]([C:5]1[CH:6]=[C:7]([C:12]([OH:14])=O)[S:8][C:9]=1[CH:10]=[O:11])[CH3:4].C([O:17][C:18](=[O:34])[CH2:19][CH2:20][C:21]1[C:26]([CH3:27])=[CH:25][C:24]([C:28](=[NH:31])[NH:29]O)=[CH:23][C:22]=1[CH2:32][CH3:33])C>CO>[CH2:32]([C:22]1[CH:23]=[C:24]([C:28]2[N:29]=[C:12]([C:7]3[S:8][C:9]([CH:10]=[O:11])=[C:5]([CH2:3][CH3:4])[CH:6]=3)[O:14][N:31]=2)[CH:25]=[C:26]([CH3:27])[C:21]=1[CH2:20][CH2:19][C:18]([OH:34])=[O:17])[CH3:33]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 200677334-Ethyl-5-formyl-thiophene-2-carboxylic acidHCID 178470908HCID 178470908, 화합물

생성물 1

HCID 866464523-(2-Ethyl-4-[5-(4-ethyl-5-formyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenyl}-propionic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The title compound is prepared according to Method E followed by treating the corresponding propionic ester derivative for 1 h at rt with 1 N aq. NaOH in methanol starting from 4-ethyl-5-formyl-thiophene-2-carboxylic acid and 3-[2-ethyl-4-(N-hydroxycarbamimidoyl)-6-methyl-phenyl]-propionic acid ethyl ester; LC-MS: tR=0.87 min; [M+1]+=399.20.

출처 및 근거

ORD 기록
ord-f8f3008e3d9742c0bdfbcaf43f63633b
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08148410B2

연결된 노트

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