홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Acetaldehyde → HCID 57700050, 화합물

HRID 1686011
노트
인쇄 미리보기

반응식

HRID 1686011 반응식
[CH:1]1([O:6][C:7](=[O:41])[C@@H:8](N)[CH2:9][CH2:10][O:11][C:12]2[CH:21]=[C:20]3[C:15]([C:16]([O:22][C:23]4[CH:28]=[CH:27][C:26]([NH:29][C:30](=[O:37])[C:31]5[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=5)=[CH:25][CH:24]=4)=[CH:17][CH:18]=[N:19]3)=[CH:14][C:13]=2[O:38][CH3:39])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:42](=O)[CH3:43].[C:45]([BH3-])#[N:46].[Na+].[CH3:49]O>C(O)(=O)C>[CH:1]1([O:6][C:7](=[O:41])[C@@H:8]([N:46]([CH2:45][CH3:49])[CH2:42][CH3:43])[CH2:9][CH2:10][O:11][C:12]2[CH:21]=[C:20]3[C:15]([C:16]([O:22][C:23]4[CH:28]=[CH:27][C:26]([NH:29][C:30](=[O:37])[C:31]5[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=5)=[CH:25][CH:24]=4)=[CH:17][CH:18]=[N:19]3)=[CH:14][C:13]=2[O:38][CH3:39])[CH2:2][CH2:3][CH2:4][CH2:5]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 177AcetaldehydeHCID 887MethanolHCID 5003444Sodium cyanoborohydrideHCID 11949608HCID 11949608, 화합물

생성물 1

HCID 57700050HCID 57700050, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid촉매

실험 절차

To (S)-2-Amino-4-[4-(4-benzoylamino-phenoxy)-6-methoxy-quinolin-7-yloxy]-butyric acid cyclopentyl ester (37 mg, 0.066 mmol) in anhydrous methanol (1 ml) were added acetaldehyde (4.1 μL, 0.073 mmol) and 1 drop of acetic acid. The reaction mixture was stirred at room temperature for 3 hours. Sodium cyanoborohydride (10.3 mg, 0.165 mmol) was then added and the reaction was left stirring overnight at room temperature, prior to concentration under vacuum. Purification was achieved on a prepacked Si-column followed by preparative HPLC, to provide the title compound as a di-TFA salt (10 mg, 18% yield)

후처리

  1. waitthe reaction was left
  2. stirringstirring overnight at room temperature
  3. concentrationto concentration under vacuum
  4. customPurification

출처 및 근거

ORD 기록
ord-f492d140413a47dd8e772b10172e231e
출처 데이터셋
uspto-grants-2012_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08148531B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트