Hydrazine hydrate (1:1) → 4-Hydrazinylpyridin-2(1H)-one

HRID 1686018노트

반응식

HRID 1686018 반응식
[OH:1][C:2]1[CH:7]=[C:6](O)[CH:5]=[CH:4][N:3]=1.O.[NH2:10][NH2:11]>COCCO>[NH:10]([C:6]1[CH:5]=[CH:4][NH:3][C:2](=[O:1])[CH:7]=1)[NH2:11]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 178516518HCID 178516518, 화합물

생성물 1

HCID 136108294-Hydrazinylpyridin-2(1H)-one수율 88.3%

시약·촉매·용매 1

HCID 80192-Methoxyethanol용매

실험 절차

2,4-dihydroxypyridine (20.3 g, 183.0 mmol) was added to the mixture of 2-methoxyethanol (400 ml) and 55% solution of hydrazine hydrate (80 ml) at room temperature. The reaction mixture was refluxed under stirring for 24 hours and then concentrated under reduced pressure. The resulting residue was recrystallized with ethanol to give the titled compound as a white solid. (Yield: 88.3%)

후처리

  1. temperatureThe reaction mixture was refluxed
  2. concentrationconcentrated under reduced pressure
  3. customThe resulting residue was recrystallized with ethanol

출처 및 근거

ORD 기록
ord-7083380ba142451c9192d036c6168634
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08148529B2

반응 노트

불러오는 중…