Pentenone → 4-Methyl-5-(trimethylsilyl)pentan-2-one

HRID 1686133

반응식

HRID 1686133 반응식
[CH3:1][C:2](=[O:6])[CH:3]=[CH:4][CH3:5].Cl[Mg][CH2:9][Si:10]([CH3:13])([CH3:12])[CH3:11]>C(OCC)C>[CH3:5][CH:4]([CH2:9][Si:10]([CH3:13])([CH3:12])[CH3:11])[CH2:3][C:2](=[O:6])[CH3:1]

참가 물질

4

반응물 2

HCID 12248PentenoneHCID 178418680HCID 178418680, 화합물

생성물 1

HCID 866437884-Methyl-5-(trimethylsilyl)pentan-2-one수율 43%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A solution of 8.00 g pent-3-en-2-one in 50 mL dry diethyl ether was dropped to a solution of 73.5 mL of chloro[(trimethylsilyl)methyl]magnesium (1.0M in diethyl ether) and 955 mg of CuBr at −5° C. under Argon. The mixture was stirred for 1 hour at room temperature. An aqueous work-up followed by silica gel chromatography yielded 5.20 g (43%) of a colourless oil.

출처 및 근거

ORD 기록
ord-4a4bf6f84aee42c39db133cf56d29530
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08148538B2

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