Acetone → Methyl(4-chloro-3-methoxyphenyl)acetate
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8]C(O)=O)=[CH:4][C:3]=1[OH:12].S([O:18][CH3:19])(OC)(=O)=O.[C:20](=[O:23])([O-])[O-].[K+].[K+].[CH3:26]C(C)=O>O>[CH3:20][O:23][C:19](=[O:18])[CH2:8][C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([O:12][CH3:26])[CH:4]=1참가 물질
6
실험 절차
The product of example 1 step (iii) (1 g), dimethyl sulfate (1 ml), potassium carbonate (1.48 g) and acetone (20 ml) were charged to a flask and heated at reflux for 16 h. The reaction was diluted with water, extracted with EtOAc, dried (MgSO4) and evaporated under reduced pressure to give the subtitle compound (1.5 g).
후처리
- temperatureheated
- temperatureat reflux for 16 h
- extractionextracted with EtOAc
- dry with materialdried (MgSO4)
- customevaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-79a0e8db07cf4083a40355f7741959dd
- 출처 데이터셋
- uspto-grants-2012_04
- 특허 번호
- US08148572B2
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