Acetic Acid → HCID 86633984, 화합물

반응식

[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][CH3:9])=[O:7])=[C:4]([NH:12][C:13]2[C:18]([Cl:19])=[CH:17][N:16]=[C:15]([Cl:20])[N:14]=2)[CH:3]=1.[C:21](OC(=O)C)(=[O:23])[CH3:22].C1COCC1.C(O)(=O)C>>[C:21]([NH:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][CH3:9])=[O:7])=[C:4]([NH:12][C:13]2[C:18]([Cl:19])=[CH:17][N:16]=[C:15]([Cl:20])[N:14]=2)[CH:3]=1)(=[O:23])[CH3:22]

참가 물질

반응물 4

HCID 176Acetic Acid

HCID 7918Acetic Anhydride

HCID 8028Tetrahydrofuran

HCID 86633983HCID 86633983, 화합물

생성물 1

HCID 86633984HCID 86633984, 화합물

실험 절차

4-Amino-2-(2,5-dichloro-pyrimidin-4-ylamino)-N-methyl-benzamide (0.135 g, 0.000432 mol), Acetic anhydride (0.0428 mL, 0.000454 mol), THF (5 mL, 0.06 mol) and Acetic acid (0.024 mL, 0.43 mol) were stirred at rt for 16 h. Product isolated as white ppt (80 mg, 52%).