Water → 3-amino-5,5-dimethyl-8-nitro-3,4-dihydro-1H-1-benzazepin-2-one

HRID 1687635노트

반응식

HRID 1687635 반응식
[N:1]([CH:4]1[CH2:10][C:9]([CH3:12])([CH3:11])[C:8]2[CH:13]=[CH:14][C:15]([N+:17]([O-:19])=[O:18])=[CH:16][C:7]=2[NH:6][C:5]1=[O:20])=[N+]=[N-].C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1COCC1.O>>[NH2:1][CH:4]1[CH2:10][C:9]([CH3:12])([CH3:11])[C:8]2[CH:13]=[CH:14][C:15]([N+:17]([O-:19])=[O:18])=[CH:16][C:7]=2[NH:6][C:5]1=[O:20]

참가 물질

5

반응물 4

HCID 962WaterHCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 866339913-Azido-5,5-dimethyl-8-nitro-1,3,4,5-tetrahydro-1-benzazepin-2-one

생성물 1

HCID 672640283-amino-5,5-dimethyl-8-nitro-3,4-dihydro-1H-1-benzazepin-2-one

실험 절차

3-Azido-5,5-dimethyl-8-nitro-1,3,4,5-tetrahydro-1-benzazepin-2-one (3.10 g, 10.3 mmol), Triphenylphosphine Resin (12 g, 11.55 mmol), THF (120 mL, 1400 mmol) and Water (0.9 mL, 50 mmol) were combined and stirred at rt for 16 h. The reaction mixture was filtered. Product isolated as a beige solid. (HPLC purity >98%)

후처리

  1. filtrationThe reaction mixture was filtered
  2. customProduct isolated as a beige solid

출처 및 근거

ORD 기록
ord-8fc24e76ef6f4f5280ec1040d7145a45
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08148391B2

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