Hydrochloric Acid → 2-(2,3-Difluoro-4-(2-hydroxyethyl)phenoxy)acetaldehyde

HRID 1689398

반응식

HRID 1689398 반응식
Cl.C([O:4][CH:5](OCC)[CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][OH:16])=[C:10]([F:17])[C:9]=1[F:18])C>O1CCOCC1.O>[F:18][C:9]1[C:10]([F:17])=[C:11]([CH2:14][CH2:15][OH:16])[CH:12]=[CH:13][C:8]=1[O:7][CH2:6][CH:5]=[O:4]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 579889892-(4-(2,2-Diethoxyethoxy)-2,3-difluorophenyl)ethanol

생성물 1

HCID 866367532-(2,3-Difluoro-4-(2-hydroxyethyl)phenoxy)acetaldehyde

시약·촉매·용매 2

HCID 962Water용매HCID 312751,4-Dioxane용매

실험 절차

Concentrated hydrochloric acid (5 mL) was added to a solution of 2-(4-(2,2-diethoxyethoxy)-2,3-difluorophenyl)ethanol (example 77, step c) (0.49 g) in 1,4-dioxane (10 mL) and the resulting mixture was stirred for 1 h. The mixture was carefully diluted with water (50 mL) and extracted with ethyl acetate (3×50 mL). The combined organics were washed with water (50 mL) and brine (50 mL), dried over sodium sulphate, filtered and evaporated to give the subtitled compound, which was used directly. Yield 0.31 g.

후처리

  1. extractionextracted with ethyl acetate (3×50 mL)
  2. washThe combined organics were washed with water (50 mL) and brine (50 mL)
  3. dry with materialdried over sodium sulphate
  4. filtrationfiltered
  5. customevaporated

출처 및 근거

ORD 기록
ord-995d961e038c419bb368d4306e5c036d
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08148373B2

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