Triethylamine → 3-(3-Fluoro-4-isocyanato-phenyl)-propionic acid tert-butyl ester

HRID 1690564노트

반응식

HRID 1690564 반응식
[C:1]([O:5][C:6](=[O:17])[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([NH2:15])=[C:11]([F:16])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].Cl[C:19](Cl)([O:21]C(=O)OC(Cl)(Cl)Cl)Cl.CCN(CC)CC>C(Cl)Cl>[C:1]([O:5][C:6](=[O:17])[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]=[C:19]=[O:21])=[C:11]([F:16])[CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 94429TriphosgeneHCID 66905628Tert-butyl 3-(4-amino-3-fluorophenyl)propanoate

생성물 1

HCID 866402673-(3-Fluoro-4-isocyanato-phenyl)-propionic acid tert-butyl ester

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

In analogy to the procedure described in example 9.1, 3-(4-amino-3-fluoro-phenyl)-propionic acid tert-butyl ester was reacted with triphosgene in the presence of Et3N in CH2Cl2 under reflux conditions for 20 h to give the title compound as yellow oil which was used in the next step without further purification. MS: m/e=265.1 [M+].

출처 및 근거

ORD 기록
ord-e95c33b171d949e58ecc0610fb2bd4ec
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08153663B2

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